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What is one of the therapeutic uses of Valproate?
- A. Suppression of seizure activity
- B. Replacement of hypothyroidism to restore normal hormone balance
- C. Maintenance of blood glucose
- D. Lowering of blood pressure
Correct Answer: A
Rationale: Valproate, also known as Valproic acid, is commonly used in medicine for the suppression of seizure activity. It is an anticonvulsant medication that helps manage and prevent seizures in various conditions such as epilepsy. While it is not used for replacing hypothyroidism, maintaining blood glucose levels, or lowering blood pressure, its primary therapeutic use is in managing seizures.
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Which statement is accurate concerning the use of aspirin (ASA) to treat pain?
- A. High doses are necessary (1 gram) to achieve anticoagulant effects.
- B. Enteric-coated capsules are available to reduce GI side effects.
- C. Increase consumption of herbs such as garlic and ginger to potentiate the anti-inflammatory effects.
- D. In low doses (325 mg), it significantly reduces inflammation.
Correct Answer: B
Rationale: Aspirin's use for pain involves anti-inflammatory and analgesic properties, but it risks GI irritation. Enteric-coated capsules minimize this by dissolving in the intestine, not the stomach, reducing bleeding risk—an accurate statement. High doses are true for anticoagulation, not pain relief, where lower doses suffice. Herbs like garlic and ginger increase bleeding risk, not inflammation relief, making it dangerous advice. Low doses (choice D, 325 mg) primarily prevent clotting, not significantly reduce inflammation, which requires higher doses. Choice B correctly reflects a practical measure to enhance aspirin's safety profile for pain management.
A client has been prescribed Methotrexate to treat Rheumatoid Arthritis. Which of the following instructions should the nurse provide?
- A. Take this medication with food to prevent nausea.
- B. Avoid alcohol while taking this medication.
- C. Wear sunscreen when outdoors while taking this medication.
- D. Take this medication on an empty stomach.
Correct Answer: B
Rationale: Methotrexate is hepatotoxic, and avoiding alcohol is crucial to prevent liver damage. However, Option A (Take this medication with food to prevent nausea) could also be correct, as Methotrexate commonly causes nausea, and taking it with food can help alleviate this side effect. However, the most important instruction is to avoid alcohol due to the risk of liver toxicity.
What is a severe adverse effect of iron supplementation?
- A. Seizures
- B. Dry mouth
- C. Edema
- D. Serotonin syndrome
Correct Answer: A
Rationale: A severe adverse effect of iron supplementation is seizures. Iron toxicity can lead to symptoms such as abdominal pain, vomiting, bloody diarrhea, lethargy, and in severe cases, seizures. It is important for individuals taking iron supplements to follow recommended dosages to prevent adverse effects.
A client with Hodgkin's disease is receiving Cyclophosphamide IV. Which medication should be administered concurrently to prevent an adverse effect of Cyclophosphamide?
- A. Uroprotectant agent, such as mesna
- B. Opioid, such as morphine
- C. Loop diuretic, such as furosemide
- D. H1 receptor antagonist, such as diphenhydramine
Correct Answer: A
Rationale: Mesna, an uroprotectant agent, is administered with nitrogen mustard chemotherapy drugs like Cyclophosphamide to prevent hemorrhagic cystitis, a common adverse effect. Mesna works by binding to and inactivating the toxic metabolites of Cyclophosphamide in the bladder, thereby reducing the risk of bladder toxicity.
Restoration of blood flow results through the dissolution of clot by:
- A. fibrin
- B. plasmin
- C. thrombin
- D. prothrombin
Correct Answer: B
Rationale: Plasmin is an enzyme that is responsible for breaking down fibrin, a protein that forms blood clots. When an area of vessel needs to have its blood flow restored, such as after a clot has formed, plasmin is activated to dissolve the clot. By breaking down the fibrin mesh of the clot, plasmin helps restore normal blood flow in the affected vessel. Therefore, the restoration of blood flow results through the dissolution of clot by plasmin, making option B the correct answer.