Nokea
A child is undergoing remission induction therapy to treat leukemia. Allopurinol is included in the regimen. The main reason for administering allopurinol as part of the client’s chemotherapy regimen is to:
- A. Prevent metabolic breakdown of xanthine to uric acid
- B. Prevent uric acid from precipitating in the ureters
- C. Enhance the production of uric acid to ensure adequate excretion of urine
- D. Ensure that the chemotherapy doesn’t adversely affect the bone marrow
Correct Answer: A
Rationale: Allopurinol prevents the breakdown of xanthine to uric acid, reducing the risk of uric acid nephropathy during chemotherapy-induced tumor lysis.
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True statements about the use of the new Child Health Foundation growth charts include:
- A. Immediate referral is advised if the height of a child is on the second centile
- B. The midparental height of a child, whose parents are 176 and 160 cm tall, is 175 cm
- C. They can be used for all children including those with Down's syndrome
- D. The target centile range for a girl is midparental height ± 10 cm
Correct Answer: C
Rationale: The growth charts are designed to be inclusive and can be used for children with Down's syndrome, among others.
Specific receptor defects occur in:
- A. Guillain-Barre syndrome
- B. Myasthenia gravis
- C. Graves' disease
- D. Ulcerative colitis
Correct Answer: B
Rationale: Myasthenia gravis is characterized by antibodies against acetylcholine receptors at the neuromuscular junction, leading to muscle weakness.
In scabies:
- A. Itching is due to sensitisation by the mite
- B. Vesicles may be seen in children
- C. The organism is easily demonstrated
- D. Spread can occur through clothes and bedding
Correct Answer: A
Rationale: Itching in scabies is due to an allergic reaction to the mites and their products, leading to sensitization.
Causes of non-bloody diarrhoea include:
- A. Shigella dysentery
- B. Campylobacter jejuni
- C. Giardia lamblia
- D. Salmonella
Correct Answer: C
Rationale: Giardia lamblia is a common cause of non-bloody diarrhoea. Shigella and Campylobacter typically cause bloody diarrhoea.
Dubowitz criteria to assess gestational age include:
- A. Skin colour
- B. Breast tissue
- C. Popliteal angle
- D. Moro reflex
Correct Answer: B
Rationale: Breast tissue is one of the criteria used in the Dubowitz assessment to estimate gestational age. Skin colour, popliteal angle, and Moro reflex are not part of the Dubowitz criteria.