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How does estrogen work in COC pills?

  • A. inhibits ovulation through suppression of LH hormone
  • B. provides most of the contraceptive effect of the COC
  • C. stabilizes the endometrium for less unscheduled bleeding
  • D. inhibits sperm penetration by thickening cervical mucus
Correct Answer: A

Rationale: Estrogen in combined oral contraceptive (COC) pills works primarily by inhibiting ovulation through the suppression of the luteinizing hormone (LH) surge. By maintaining consistent levels of estrogen in the body, COC pills prevent the release of eggs from the ovary. This prevents fertilization from occurring, which is one of the main mechanisms of action of COC pills to provide contraception. While estrogen also has other effects such as stabilizing the endometrium to reduce unscheduled bleeding, its main role in COC pills is to inhibit ovulation and prevent pregnancy through hormonal regulation.