Brunner & Suddarth's Textbook of Medical-Surgical Nursing 14e (Hinkle 2017) - Pain Management Related

Review Brunner & Suddarth's Textbook of Medical-Surgical Nursing 14e (Hinkle 2017) - Pain Management related questions and content

A 74-year-old woman was diagnosed with rheumatoid arthritis 1 year ago, but has achieved adequate symptom control through the regular use of celecoxib (Celebrex), a COX-2 selective NSAID. The nurse should recognize that this drug, like other NSAIDs, influences what aspect of the pathophysiology of nociceptive pain?

  • A. Distorting the action potential that is transmitted along the A-delta (d) and C fibers
  • B. Diverting noxious information from passing through the dorsal root ganglia and synapses in the dorsal horn of the spinal cord
  • C. Blocking modulation by limiting the reuptake of serotonin and norepinephrine
  • D. Inhibiting transduction by blocking the formation of prostaglandins in the periphery
Correct Answer: D

Rationale: NSAIDs produce pain relief primarily by blocking the formation of prostaglandins in the periphery; this is a central component of the pathophysiology of transduction. NSAIDs do not act directly on the aspects of transmission, perception, or modulation of pain that are listed.