Fundamentals of Nursing Nursing Process Questions Related

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A client is receiving methotrexate (Mexate), 12g/m2 IV to treat osteogenic carcinoma. During methotrexate therapy, the nurse expects the client to receive which other drug to protect normal cells?

  • A. Probenecid (Benemid)
  • B. Cytarabine (ara-C, cystosine arabinoside [Cytosar-U])
  • C. Thioguanine (6-thioguanine, 6-TG)
  • D. Leucovorin (Citrovorum factor or folinic acid [wellcovirin])
Correct Answer: D

Rationale: The correct answer is D: Leucovorin. Leucovorin is given during methotrexate therapy to protect normal cells by acting as a rescue agent that helps to reduce the toxic effects of methotrexate. It works by enhancing the efficacy of methotrexate in cancer cells while reducing its toxicity in normal cells. Probenecid (A) is not used to protect normal cells during methotrexate therapy. Cytarabine (B) and Thioguanine (C) are other chemotherapeutic agents and are not typically given to protect normal cells during methotrexate therapy.