NCLEX PN Practice Test Related

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A client taking Zoloft (sertraline) tells the nurse that she has also been taking St. John's wort. The nurse should report this information to the doctor because:

  • A. The two substances have opposing effects.
  • B. The amount of medication may be reduced.
  • C. Herbals only provide a placebo effect.
  • D. It will be necessary to increase the dosage.
Correct Answer: B

Rationale: St. John's wort can induce the metabolism of Zoloft, potentially reducing its effectiveness, so the doctor may need to adjust the dose. Answer A is incorrect as they do not have opposing effects. Answer C is incorrect as St. John's wort has pharmacological effects. Answer D is incorrect as increasing the dose may not be necessary.