ATI Pharmacology Test Bank Related

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A client with Hodgkin's disease is receiving Cyclophosphamide IV. Which medication should be administered concurrently to prevent an adverse effect of Cyclophosphamide?

  • A. Uroprotectant agent, such as mesna
  • B. Opioid, such as morphine
  • C. Loop diuretic, such as furosemide
  • D. H1 receptor antagonist, such as diphenhydramine
Correct Answer: A

Rationale: Mesna, an uroprotectant agent, is administered with nitrogen mustard chemotherapy drugs like Cyclophosphamide to prevent hemorrhagic cystitis, a common adverse effect. Mesna works by binding to and inactivating the toxic metabolites of Cyclophosphamide in the bladder, thereby reducing the risk of bladder toxicity.