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A client with leukemia who has been receiving Trimetrexate (methotrexate) has an order for Wellcovorin (leucovorin). The rationale for administering Wellcovorin is to:

  • A. Treat anemia caused by the methotrexate
  • B. Create a synergistic effect that shortens treatment time
  • C. Increase the number of circulating neutrophils
  • D. Reverse drug toxicity and prevent tissue damage
Correct Answer: D

Rationale: Leucovorin (Wellcovorin) is a rescue therapy given after methotrexate to reverse its toxicity and protect healthy cells from damage particularly in bone marrow and mucosal tissues. It does not treat anemia enhance synergy or increase neutrophils.