Medical Surgical Nursing NCLEX RN Questions Related

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A client with peripheral vascular disease and chronic obstructive pulmonary disease takes theophylline (Theo-Dur) 200 mg twice daily every day. The physician is considering adding pentoxifylline (Trental) to the regimen. The nurse should be aware that:

  • A. The combination may increase the risk of bleeding
  • B. The combination may increase theophylline levels
  • C. The combination may cause severe hypotension
  • D. The combination is contraindicated
Correct Answer: B

Rationale: Pentoxifylline may increase theophylline levels by inhibiting its metabolism, potentially leading to toxicity (e.g., nausea, tachycardia). The nurse should monitor theophylline levels and symptoms. Bleeding risk, severe hypotension, or contraindication are not documented interactions.