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A depressed patient is receiving imipramine (Tofranil) 300 mg daily. Which side effect requires seeking medical attention?

  • A. Dry mouth
  • B. Blurred vision
  • C. Nasal congestion
  • D. Urinary retention
Correct Answer: D

Rationale: The correct answer is D: Urinary retention. Imipramine is known to cause anticholinergic side effects, such as urinary retention. This side effect is serious and requires immediate medical attention to prevent complications like bladder distention or urinary tract infections. Dry mouth and blurred vision are common but less urgent side effects of imipramine, while nasal congestion is not typically associated with this medication. Thus, urinary retention stands out as the side effect requiring immediate medical attention among the choices provided.