Nokea
A group of nursing students are reviewing information about drug development in the United States in preparation for an exam. The students demonstrate understanding of this material when they identify testing of which of the following as one of the first steps?
- A. Small group of healthy volunteers
- B. People who have the disease
- C. Live animals
- D. Large numbers of patients
Correct Answer: C
Rationale: Initially, drug testing begins with testing in an artificial environment such as a test tube, and then this testing is followed by testing on live animals. Next, clinical testing occurs with each phase involving a larger number of people. First, a small group of 20 to 100 healthy volunteers are tested; then testing is performed on people who have the disease or condition. Last, the drug is given to large numbers of patients in medical research centers.
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A nurse is assessing a client after administering a prescribed medication. Which of the following would alert the nurse to suspect that the client is developing anaphylactic shock? Select all that apply.
- A. Bradycardia
- B. Hypertension
- C. Dyspnea
- D. Urticaria
- E. Angioedema
Correct Answer: C,D,E
Rationale: The symptoms of anaphylactic shock are dyspnea, feeling of fullness in the throat, cough, wheezing, extremely low blood pressure, tachycardia (heart rate =100 bpm), palpitations, syncope, cardiac arrest, urticaria, angioedema, pruritus, sweating, nausea, vomiting, and abdominal pain.
The nurse observes that after administration of a drug the patient has developed itching and a skin rash. The nurse interprets these findings as which of the following?
- A. Toxicity
- B. Allergic reaction
- C. Angioedema
- D. Crystalluria
Correct Answer: B
Rationale: Allergic reactions are manifested by a variety of signs and symptoms including itching, skin rashes, and hives. Swollen eyelids, lips, and mouth are some of the symptoms of angioedema, an allergic drug reaction that may block the airway, causing asphyxia. Toxicity or toxic reactions are caused when blood concentration levels exceed the therapeutic level of drugs. Reduced blood pressure is called hypotension. Crystals in the urine are symptoms of crystalluria.
A nursing student is reviewing information about the Controlled Substances Act of 1970. The student would expect to find which of the following as being regulated for drugs classified as controlled substances? Select all that apply.
- A. Manufacturing
- B. Elimination
- C. Distribution
- D. Formulation
- E. Dispensing
Correct Answer: A,C,E
Rationale: The Controlled Substances Act of 1970 regulates the manufacture, distribution, and dispensing of drugs classified as controlled substances. Elimination refers to the excretion of drugs from the body, a pharmacokinetic activity. The act does not address formulation of the drug.
The nurse administers a prescribed medication that is supplied as an enteric-coated tablet. The patient asks the nurse about this form of tablet. When describing how this tablet is absorbed, which response by the nurse would be most accurate?
- A. The medication dissolves directly from the stomach into the body.
- B. The drug breaks up into pieces as it moves through the stomach.
- C. The medication bypasses the GI tract and goes quickly into the bloodstream.
- D. The drug dissolves into fragments after it reaches your small intestine.
Correct Answer: D
Rationale: Enteric-coated tablets disintegrate or fragment after reaching the alkaline medium of the small intestine. Tablets and capsules break up into small particles and dissolve into body fluids in the gastrointestinal tract. Liquids and parenteral drugs are quickly absorbed into the body system.
When describing the various types of medications to a group of nursing students, a nursing instructor would identify which of the following as a source for deriving medications? Select all that apply.
- A. Plants
- B. Synthetic sources
- C. Mold
- D. Minerals
- E. Animals
Correct Answer: A,B,C,D,E
Rationale: Medications are derived from natural sources, for example, plants, molds, minerals, and animals, as well as created synthetically in a laboratory.