Fundamentals of Nursing HESI Related

Review Fundamentals of Nursing HESI related questions and content

A healthcare professional is reviewing a client's medications. They include cimetidine and imipramine. Knowing that cimetidine decreases the metabolism of imipramine, the healthcare professional should identify that this combination is likely to result in which of the following effects?

  • A. Decreased therapeutic effects of cimetidine
  • B. Increased risk of imipramine toxicity
  • C. Decreased risk of adverse effects of cimetidine
  • D. Increased therapeutic effects of imipramine
Correct Answer: B

Rationale: When cimetidine decreases the metabolism of imipramine, it leads to an increased concentration of imipramine in the body, which can result in imipramine toxicity. This increased risk of toxicity is the likely effect of this drug interaction. Choice A is incorrect because cimetidine's effect on imipramine metabolism does not impact the therapeutic effects of cimetidine. Choice C is incorrect because the interaction does not decrease the risk of adverse effects of cimetidine. Choice D is incorrect as the increased concentration of imipramine can lead to toxicity, not increased therapeutic effects.