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A nurse is caring for a 77-year-old patient. The nurse would know that a normal physiologic change that must be considered when planning drug therapy, and is associated with aging is what?
- A. Blood volume decreases
- B. Subcutaneous tissue increases
- C. Total body water increases
- D. Muscle mass increases
Correct Answer: A
Rationale: Aging reduces blood volume, altering drug distribution and requiring dosage adjustments.
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A group of nursing students are reviewing information about drug development in the United States in preparation for an exam. The students demonstrate understanding of this material when they identify testing of which of the following as one of the first steps?
- A. Small group of healthy volunteers
- B. People who have the disease
- C. Live animals
- D. Large numbers of patients
Correct Answer: C
Rationale: Initially, drug testing begins with testing in an artificial environment such as a test tube, and then this testing is followed by testing on live animals. Next, clinical testing occurs with each phase involving a larger number of people. First, a small group of 20 to 100 healthy volunteers are tested; then testing is performed on people who have the disease or condition. Last, the drug is given to large numbers of patients in medical research centers.
The bronchodilator of choice for patients taking propranolol is:
- A. Albuterol
- B. Pirbuterol
- C. Formoterol
- D. Ipratropium
Correct Answer: D
Rationale: Ipratropium , an anticholinergic, avoids beta-blockade interference from propranolol, unlike beta-agonists .
Which priority action should be implemented when hives are assessed on a patient started on a new medication?
- A. Notify physician of allergic reaction
- B. Notify physician of idiosyncratic reaction
- C. Notify physician of potential teratogenicity
- D. Notify physician of potential tolerance
Correct Answer: A
Rationale: Hives indicate an allergic reaction (hypersensitivity), requiring immediate physician notification for management.
A nurse is preparing to administer Amoxicillin 20 mg/kg/day PO to divide equally every 12 hr to a preschooler who weighs 44 lb. The amount available is amoxicillin suspension 250 mg/5 mL. how many mL should the nurse administer per dose? (Round the answer to the nearest whole number. Do not use a trailing zero.)
- A. 4
- B. 7
- C. 1
- D. 10
Correct Answer: A
Rationale: Calculation: 44 lb = 20 kg; 20 mg/kg/day 20 kg = 400 mg/day; 400 mg ÷ 2 doses = 200 mg/dose; 200 mg ÷ (250 mg/5 mL) = 4 mL, matching the answer.
When the costs of a specific treatment or intervention are calculated and then compared with the dollar value of the benefit received it is referred to as:
- A. Cost-minimization analysis
- B. Cost-of-illness analysis
- C. Cost-effectiveness analysis
- D. Cost-benefit analysis
Correct Answer: D
Rationale: Cost-benefit analysis quantifies both costs and benefits in monetary terms.