Roach's Introductory Clinical Pharmacology 11th Edition - Antianginal and Vasodilating Drugs Related

Review Roach's Introductory Clinical Pharmacology 11th Edition - Antianginal and Vasodilating Drugs related questions and content

A nurse reviews a clients medication history for drugs that might interact with the client's prescribed nitrate therapy. Which of the following if administered with nitrates would the nurse identify as causing severe hypotension and possible cardiovascular collapse? Select all that apply.

  • A. Alcohol
  • B. Beta-2 agonists
  • C. HMG-CoA reductase inhibitors
  • D. Angiotensin-converting enzyme inhibitors
  • E. Phosphodiesterase inhibitors
Correct Answer: A,E

Rationale: Alcohol and phosphodiesterase inhibitors when administered with nitrates can cause severe hypotension and possible cardiovascular collapse.