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A nursing instructor is preparing a teaching plan for a group of nursing students about macrolide antibacterial drugs. Which of the following would the instructor expect to include? Select all that apply.
- A. Macrolides are broad-spectrum antibiotics.
- B. Macrolides are contraindicated in clients with renal dysfunction.
- C. Macrolides may cause visual disturbances.
- D. Macrolides can be used in clients allergic to penicillins.
- E. Macrolides can be used to treat acne vulgaris.
Correct Answer: A, C, D, E
Rationale: Macrolides are broad-spectrum antibiotics that can be used in clients with penicillin allergies and can be used to treat acne vulgaris. Macrolides can cause visual disturbances and are contraindicated in clients with pre-existing liver disease.
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A nursing instructor is preparing a teaching plan for a group of nursing students about macrolide antibacterial drugs. Which of the following would the instructor expect to include? Select all that apply.
- A. Macrolides are broad-spectrum antibiotics.
- B. Macrolides are contraindicated in clients with renal dysfunction.
- C. Macrolides may cause visual disturbances.
- D. Macrolides can be used in clients allergic to penicillins.
- E. Macrolides can be used to treat acne vulgaris.
Correct Answer: A, C, D, E
Rationale: Macrolides are broad-spectrum antibiotics that can be used in clients with penicillin allergies and can be used to treat acne vulgaris. Macrolides can cause visual disturbances and are contraindicated in clients with pre-existing liver disease.
A nurse suspects that a patient receiving an aminoglycoside is developing neurotoxicity based on assessment of which of the following? Select all that apply.
- A. Paresthesias
- B. Tingling around the mouth
- C. Ringing in the ears
- D. Vertigo
Correct Answer: A, B, E
Rationale: Signs and symptoms of neurotoxicity include numbness, skin tingling, circumoral (around the mouth) paresthesia, peripheral paresthesia, tremors, muscle twitching, convulsions, muscle weakness, and neuromuscular blockade (acute muscular paralysis and apnea). Ringing in the ears and vertigo would suggest ototoxicity.
A nurse is preparing to administer an aminoglycoside to a client. The nurse would be alert for the development of which of the following toxicities? Select all that apply.
- A. Nephrotoxicity
- B. Cardiotoxicity
- C. Ototoxicity
- D. Hepatotoxicity
Correct Answer: A, C, E
Rationale: More serious adverse reactions of aminoglycosides include nephrotoxicity, ototoxicity, and neurotoxicity. A nurse recognizing these can greatly reduce permanent damage to the client's hearing, kidneys, and nerves. Aminoglycosides are not associated with cardiotoxicity or hepatotoxicity.
A client is receiving quinupristin/dalfopristin via a peripheral intravenous infusion. After the drug is administered, the nurse would flush the intravenous line with which of the following?
- A. Normal saline
- B. 0.45% sodium chloride
- C. Dextrose 5% and water
- D. Heparin
Correct Answer: C
Rationale: Quinupristin/dalfopristin is irritating to the vein. After peripheral infusion, the vein should be flushed with 5% dextrose in water (D5W), because the drug is incompatible with saline or heparin flush solutions.
A client is receiving gentamicin. Assessment of which of the following would lead the nurse to suspect that the client is developing nephrotoxicity? Select all that apply.
- A. Proteinuria
- B. Hematuria
- C. Decreased urine output
- D. Increased serum creatinine
Correct Answer: A, B, C, D
Rationale: Proteinuria, hematuria, decreased urine output, increased serum creatinine, and increased blood nitrogen urea (BUN) are suggestive of nephrotoxicity. Decreased fluid intake would support dehydration.