Nokea
A patient is infected by invasive aspergillosis, and the medical history reveals that the patient has not been able to tolerate several antifungal drugs. The nurse anticipates an order for which medication to treat this infection?
- A. Fluconazole
- B. Micafungin
- C. Caspofungin
- D. Nystatin
Correct Answer: C
Rationale: Caspofungin is used for treating severe infection by Aspergillus species (invasive aspergillosis) in patients who are intolerant of or refractory to other drugs.
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During therapy with amphotericin B, the nurse will monitor the patient for known adverse effects that would be reflected by which laboratory result?
- A. Serum potassium level of 2.7 mEq/L
- B. Serum potassium level of 5.8 mEq/L
- C. White blood cell count of 7000 cells/mm?³
- D. Platelet count of 300,000/microliter
Correct Answer: A
Rationale: The nurse needs to monitor for hypokalemia, a possible adverse effect of amphotericin B. A serum potassium level of 2.7 mEq/L indicates hypokalemia, which requires attention.
A patient has received a prescription for a 2-week course of antifungal suppositories for a vaginal yeast infection. She asks the nurse if there is an alternative to this medication, saying, 'I don't want to do this for 2 weeks!' Which is a possibility in this situation?
- A. A single dose of a vaginal antifungal cream
- B. A one-time infusion of amphotericin B
- C. A single dose of a fluconazole (Diflucan) oral tablet
- D. There is no better alternative to the suppositories
Correct Answer: C
Rationale: A single oral dose of fluconazole may be used to treat vaginal candidiasis.
A patient is taking nystatin oral lozenges to treat an oral candidiasis infection resulting from inhaled corticosteroid therapy for asthma. Which instruction by the nurse is appropriate?
- A. Chew the lozenges until they are completely dissolved
- B. Let the lozenges dissolve slowly and completely in your mouth without chewing it
- C. Rinse your mouth with water before taking the inhaler
- D. Rinse your mouth with mouthwash after taking the inhaler
Correct Answer: B
Rationale: Nystatin may be given orally in the form of lozenges, or troches, which need to be slowly and completely dissolved in the mouth for optimal effects; tablets are not to be chewed or swallowed whole. Patients taking an inhaled corticosteroid must rinse their mouths with water thoroughly after taking the inhaler.
The nurse is administering an amphotericin B infusion. Which actions by the nurse are appropriate? (Select all that apply.)
- A. Administering the medication by rapid IV infusion
- B. Discontinuing the drug immediately if the patient develops tingling and numbness in the extremities
- C. If adverse effects occur, reducing the IV rate gradually until they subside
- D. Using an infusion pump for IV therapy
- E. Monitoring the IV site for signs of phlebitis and infiltration
- F. Administering premedication for fever and nausea
- G. Knowing that the intravenous solution for amphotericin B will be cloudy
Correct Answer: B,D,E,F
Rationale: If the patient develops tingling and numbness in the extremities (paresthesias), discontinue the drug immediately. An infusion pump is necessary for the infusion, and the nurse will monitor the IV site for signs of phlebitis and infiltration. Premedication to reduce the adverse effects of fever, malaise, and nausea may be ordered. The IV solution must be clear and without precipitates; and muscle weakness, not twitching, may indicate hypokalemia. The medication must be administered at the rate recommended and stopped, not slowed, if adverse reactions occur.
The nurse is reviewing instructions for vaginal antifungal drugs with a patient. Which statement by the nurse is an appropriate instruction regarding these drugs?
- A. The medication can be stopped when your symptoms are relieved.
- B. Discontinue this medication if menstruation begins.
- C. Daily douching is part of the treatment for vaginal fungal infections.
- D. Abstain from sexual intercourse until the treatment has been completed and the infection has resolved.
Correct Answer: D
Rationale: Female patients taking antifungal medications for the treatment of vaginal infections need to abstain from sexual intercourse until the treatment has been completed and the infection has resolved. The medication needs to be taken for as long as prescribed. Instruct patients to continue to take the medication even if they are actively menstruating. Douching is not an appropriate intervention.