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A patient presents with a well-demarcated, hyperpigmented patch with irregular borders and asymmetric color distribution on the face. The lesion has increased in size over the past few months. Which of the following conditions is most concerning for this presentation?

  • A. Melanocytic nevus (mole)
  • B. Lentigo simplex
  • C. Seborrheic keratosis
  • D. Melanoma
Correct Answer: D

Rationale: The presentation described, including a well-demarcated, hyperpigmented patch with irregular borders, asymmetric color distribution, and increase in size over a short period, is concerning for melanoma. Melanoma is a type of skin cancer that arises from melanocytes, the cells that produce pigment in the skin. The irregular borders, color variation, and growth over time are classic signs of melanoma. Melanomas are potentially dangerous and should be evaluated promptly by a healthcare provider for proper diagnosis and treatment. It is important to distinguish melanoma from other benign lesions like melanocytic nevus (mole), lentigo simplex, and seborrheic keratosis, as early detection and treatment of melanoma can significantly impact patient outcomes.