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A patient presents with severe headache, blurred vision, and fatigue. Laboratory tests reveal elevated white blood cell count, thrombocytosis, and presence of JAK2 V617F mutation. Which of the following conditions is most likely to cause these findings?

  • A. Polycythemia vera
  • B. Essential thrombocythemia
  • C. Chronic myeloid leukemia (CML)
  • D. Myelofibrosis
Correct Answer: B

Rationale: The patient's presentation of severe headache, blurred vision, and fatigue, along with the laboratory findings of elevated white blood cell count, thrombocytosis, and JAK2 V617F mutation, are characteristic of essential thrombocythemia. This is a myeloproliferative neoplasm characterized by the clonal proliferation of megakaryocytes, leading to an increased platelet count. The JAK2 V617F mutation is commonly found in essential thrombocythemia and other myeloproliferative disorders. The symptoms of essential thrombocythemia can be related to the increased blood viscosity and risk of thrombosis due to the elevated platelet count. Polycythemia vera would present with elevated red blood cell count, hemoglobin, and hematocrit, along with other features such as pruritus after a hot bath. Chronic myeloid leukemia (CML