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A patient with diabetes mellitus presents with polyuria, polydipsia, nocturia, and fatigue. Laboratory findings reveal hyperglycemia, glycosuria, and ketonuria. What is the most likely diagnosis?

  • A. Diabetic nephropathy
  • B. Diabetic ketoacidosis (DKA)
  • C. Hyperosmolar hyperglycemic state (HHS)
  • D. Diabetic autonomic neuropathy
Correct Answer: B

Rationale: The presentation of a patient with diabetes mellitus showing symptoms of polyuria, polydipsia, nocturia, and fatigue along with laboratory findings of hyperglycemia, glycosuria, and ketonuria is indicative of diabetic ketoacidosis (DKA). DKA is a serious complication of diabetes characterized by hyperglycemia, metabolic acidosis, and ketosis. The increased glucose levels lead to glycosuria, causing osmotic diuresis resulting in polyuria, polydipsia, and nocturia. The body starts breaking down fats for energy in the absence of sufficient insulin, leading to the production of ketones causing ketonuria. The patient may also experience fatigue due to the metabolic abnormalities present in DKA.