Advanced Pharmacology Test Bank Related

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ACE inhibitors…

  • A. Block the vasoconstrictor and aldosterone from producing effects of angiotensin II at the receptor site
  • B. Blocks stimulation of beta 1 and beta 2 at the receptor sites
  • C. Blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II
  • D. None of the above
Correct Answer: A

Rationale: ACE inhibitors, such as enalapril and lisinopril, work by blocking the enzyme angiotensin-converting enzyme (ACE), which is responsible for converting angiotensin I into angiotensin II. By inhibiting this conversion, ACE inhibitors prevent the vasoconstrictor and aldosterone-stimulating effects of angiotensin II at the receptor sites. This leads to vasodilation, decreased blood pressure, and reduced aldosterone secretion. This mechanism of action makes ACE inhibitors an important class of medications for managing conditions such as hypertension, heart failure, and chronic kidney disease.