After teaching a group of nursing students about the half-life of a drug, the instructor determines the need for additional teaching when the students identify which of the following as true? Select all that apply.
- A. Half-life can be decreased in clients with renal disease.
- B. Half-life can help determine dosing frequency.
- C. Half-life does not change throughout a client's life.
- D. Layer disease can increase half-life.
- E. Half-life is the measure of the rate at which drugs are removed from the body.
Correct Answer: A,C
Rationale: Half-life is the measure of the rate at which drugs are removed from the body, and any difficulty in excreting a drug increases half-life, including liver or kidney disease or advanced age.
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A patient is receiving digoxin as treatment for heart failure. Which of the following would be most important for the nurse to monitor to reduce the risk for toxicity?
- A. Seizure activity
- B. Drug blood level
- C. Urinary output
- D. Blood pressure
Correct Answer: B
Rationale: The nurse should monitor the patient's blood level of the drug to ensure that the level remains within the therapeutic range. Monitoring seizure activity, urination frequency, and blood pressure will not prevent toxicity. Seizure activity is unrelated to digoxin or heart failure.
After teaching a group of nursing students about pharmacokinetics, the instructor determines that the teaching was successful when the students identify which of the following as the first phase?
- A. Metabolism
- B. Absorption
- C. Distribution
- D. Excretion
Correct Answer: B
Rationale: Pharmacokinetics refers to the transportation activity of drugs in the body after administration. The first component is absorption. This is followed by distribution, metabolism, and finally excretion.
A nurse is preparing to administer a prescribed medication to a client. The nurse integrates knowledge of which of the following as a possible factor that could influence the drug response? Select all that apply.
- A. Age
- B. Polypharmacy
- C. Weight
- D. Sex
- E. Disease
Correct Answer: A,B,C,D,E
Rationale: Drug response can be influenced by the following factors: age, polypharmacy, weight, sex, disease, and genetics.
The nurse is helping a client review a prescription from the health care provider. When examining the prescription, which of the following would the nurse expect to find documented? Select all that apply.
- A. Name of the drug
- B. Dosage of the drug
- C. Route of drug administration
- D. Times of drug administration
- E. Licensed prescriber's signature
Correct Answer: A,B,C,D,E
Rationale: The prescription must contain the client's name, the name of the drug, the dosage, the method and times of administration, and the signature of the licensed health care provider prescribing the drug.
A nurse is reading a journal article about seasonal allergies and comes across the name of the drug loratadine. The nurse identifies this drug name as which of the following?
- A. Chemical
- B. Generic
- C. Trade
- D. Brand
Correct Answer: B
Rationale: The generic name is the name given to a drug that can be made or marketed by any company and is the name given to the drug by the FDA. The chemical name is the scientific term that describes the molecular structure of the drugs, typically the chemical components. The trade or brand name of the drug is the name selected by a specific company for marketing purposes and is followed by a trademark symbol or registered trademark symbol.
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