Nokea
All of the following are noted in Cushing's syndrome except:
- A. Psychosis
- B. Systemic hypertension
- C. Sexual precocity
- D. Osteoporosis
Correct Answer: C
Rationale: Cushing's syndrome is a collection of signs and symptoms caused by prolonged exposure to high levels of cortisol. Common features of Cushing's syndrome include weight gain, central obesity, moon face, buffalo hump, easy bruising, muscle weakness, and menstrual irregularities in women.
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In males which hormone stimulates Leydig cells to produce testosterone?
- A. Follicle stimulating hormone (FSH)
- B. Luteinizing hormone (LH)
- C. hormone
- D. insipidus
Correct Answer: B
Rationale: In males, Leydig cells in the testes are stimulated to produce testosterone by luteinizing hormone (LH). LH is produced by the anterior pituitary gland and acts on the Leydig cells to promote the synthesis and release of testosterone. This hormone plays a crucial role in male reproductive function and the development of masculine characteristics. Follicle stimulating hormone (FSH) plays a role in spermatogenesis in males but does not directly stimulate Leydig cells to produce testosterone.
The triad of hyponatraemia, haemodilution and urine hypertonic to plasma suggest diagnosis of:
- A. Nephrotic syndrome
- B. SIADH
- C. Nephrogenic diabetes insipidus
- D. Addison's disease
Correct Answer: B
Rationale: The triad of hyponatremia (low sodium levels in the blood), haemodilution (increased plasma volume), and urine hypertonic to plasma (high urine osmolality compared to blood osmolality) is characteristic of Syndrome of Inappropriate Antidiuretic Hormone (SIADH). In SIADH, there is excessive release of antidiuretic hormone (ADH), also known as vasopressin, leading to water retention by the kidneys and dilutional hyponatremia. This condition results in the body holding onto water, causing hyponatremia and dilution of the blood. The urine being hypertonic compared to plasma indicates that the kidneys are reabsorbing water effectively and concentrating the urine.
All of the following develop into dwarfism except:
- A. Congenital adrenal hyperplasia
- B. Hypopituitarism
- C. Homocystinuria
- D. Pseudohypoparathyroidism
Correct Answer: A
Rationale: Congenital adrenal hyperplasia does not lead to dwarfism. It is a group of genetic disorders that affect the adrenal glands and can cause various symptoms related to hormone imbalances. In contrast, the other conditions listed - hypopituitarism, homocystinuria, and pseudohypoparathyroidism - can all lead to dwarfism through different mechanisms. Hypopituitarism is characterized by a deficiency of pituitary hormones, including growth hormone, which can result in stunted growth and dwarfism. Homocystinuria is a metabolic disorder that can affect bone growth and lead to skeletal abnormalities resulting in dwarfism. Pseudohypoparathyroidism is a rare genetic disorder that can manifest with short stature or dwarfism due to skeletal abnormalities caused by altered bone metabolism.
Oxytocin and antidiuretic hormone (ADH; vasopressin) are:
- A. complex steroids.
- B. synthesized and stored in the posterior pituitary.
- C. released from the anterior pituitary where blood is hypotonic.
- D. synthesized in the hypothalamus and released from the posterior pituitary.
Correct Answer: D
Rationale: Oxytocin and antidiuretic hormone (ADH; vasopressin) are both synthesized in the hypothalamus, specifically in the supraoptic and paraventricular nuclei. After synthesis, they are transported along axons to the posterior pituitary where they are stored until they are released into the bloodstream when needed. This is why they are released from the posterior pituitary, not the anterior pituitary. These hormones have different functions in the body, with oxytocin being involved in labor and breastfeeding, while ADH plays a role in regulating water balance and blood pressure.
All of the following would be expected to increase prolactin levels except:
- A. Chest wall trauma
- B. Hyperthyroidism
- C. Pregnancy
- D. Renal failure
Correct Answer: B
Rationale: Prolactin levels can be increased by various factors, including chest wall trauma, pregnancy, and renal failure. However, hyperthyroidism is not typically associated with elevated prolactin levels. In fact, hyperthyroidism is more commonly associated with decreased levels of prolactin due to the inhibitory effect of thyroid hormones on prolactin secretion. Therefore, all of the options except for hyperthyroidism would be expected to increase prolactin levels.