Nokea
An 18-months old infant weighing 10 kg develops an acute anaphylactic reaction with bronchospasm towards antibiotic injection. What is the most appropriate initial treatment?
- A. Inj. Hydrocortisone 100 mg IV stat
- B. Inj. Epinephrine 0.1 mg IV / IM stat
- C. Inj. Epinephrine 0.01 mg IV/IM stat
- D. Nebulization Salbutamol + oxygen
Correct Answer: C
Rationale: The most appropriate initial treatment for anaphylaxis in a child is intramuscular epinephrine at a dose of 0.01 mg/kg, which is 0.1 mg for a 10 kg child.
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Short stature due to growth hormone deficiency:
- A. Is characteristically manifest in infancy
- B. May be secondary to irradiation to the skull
- C. Can be part of congenital hypopituitarism
- D. Is easily corrected
Correct Answer: B
Rationale: Growth hormone deficiency can result from cranial irradiation, which may damage the pituitary gland and impair hormone production.
Prader Willi syndrome:
- A. Is caused by a maternal deletion of a part of chromosome 15
- B. Presents with macrosomia in infancy
- C. Developmental delay is common
- D. Behavioural problems are common
Correct Answer: C
Rationale: Developmental delay is a common feature of Prader Willi syndrome, along with other symptoms such as hypotonia and feeding difficulties in infancy.
FISH is helpful in diagnosing:
- A. Prader-Willi syndrome
- B. Di George syndrome
- C. Klinefelter's syndrome
- D. Turner's syndrome
Correct Answer: B
Rationale: FISH (Fluorescence In Situ Hybridization) is particularly useful in diagnosing DiGeorge syndrome, which involves microdeletions on chromosome 22.
Regarding intussusception in childhood:
- A. Incidence is most common in children over 3 years of age
- B. Barium enema is the investigation of choice
- C. Patient commonly presents with constant abdominal pain
- D. It is associated with Henoch-Schoenlein purpura
Correct Answer: D
Rationale: Intussusception is associated with Henoch-Schoenlein purpura, a condition that can cause inflammation and bleeding in the small blood vessels.
Examples of cyanotic heart disease include:
- A. Ebstein's anomaly
- B. Pulmonary stenosis
- C. Coarctation of aorta
- D. Hypoplastic left heart syndrome
Correct Answer: D
Rationale: Hypoplastic left heart syndrome is a form of cyanotic heart disease. Ebstein's anomaly and pulmonary stenosis can also cause cyanosis, but coarctation of the aorta typically does not.