NCLEX PN Exam Cram Related

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An infection in a central venous access device is not eliminated by giving antibiotics through the catheter. How might bacterial glycocalyx contribute to this?

  • A. It protects the bacteria from antibiotic and immunologic destruction.
  • B. Glycocalyx neutralizes the antibiotic, rendering it ineffective.
  • C. It competes with the antibiotic for binding sites on the microbe.
  • D. Glycocalyx provides nutrients for microbial growth.
Correct Answer: A

Rationale: Bacterial glycocalyx is a viscous polysaccharide or polypeptide slime that covers microbes. It plays a significant role in protecting bacteria by enhancing adherence to surfaces, resisting phagocytic engulfment by white blood cells, and preventing antibiotics from contacting the microbe. Choice A is correct because glycocalyx shields the bacteria from both antibiotics and the immune system, allowing the infection to persist. Choices B, C, and D are incorrect because glycocalyx does not neutralize antibiotics, compete for binding sites with antibiotics, or provide nutrients for microbial growth.