ATI Fundamentals LPN Related

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Anaphylactic reaction after administering penicillin indicates

  • A. An acquired atopic sensitization
  • B. Passive immunity to penicillin allergen
  • C. Antibodies to penicillin developed after earlier use of the drug
  • D. Developed potent bivalent antibodies when the IV administration was started
Correct Answer: C

Rationale: Anaphylaxis is a severe IgE-mediated allergic reaction, occurring when prior penicillin exposure sensitizes the immune system, forming antibodies. Re-exposure triggers histamine release, causing symptoms like shock or dyspnea. Atopic sensitization relates to predisposition, not specific drug history. Passive immunity involves transferred antibodies, not self-developed ones. Bivalent antibodies forming during IV use is incorrect sensitization precedes administration. Nurses must assess allergy history, preparing for emergencies like epinephrine administration to reverse this life-threatening response.