Nokea
Cruciferous vegetables may alter drug pharmacokinetics by:
- A. Enhancing absorption of weakly acidic drugs
- B. Altering CYP 3A4 activity, leading to elevated levels of drugs, such as the statins
- C. Inducing CYP 1A2, possibly leading to therapeutic failure of drugs metabolized by CYP 1A2
- D. Decreasing first-pass metabolism of drugs
Correct Answer: C
Rationale: Cruciferous vegetables (e.g., broccoli) induce CYP1A2, accelerating metabolism of drugs like theophylline, potentially reducing efficacy.
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Most common indication for therapeutic monitoring of plasma levels of a drug is
- A. Hit & run drugs
- B. Drugs with irreversible action
- C. Narrow therapeutic range
- D. Failure of response
Correct Answer: C
Rationale: Drugs with a narrow therapeutic range (e.g., digoxin) require monitoring to avoid toxicity.
Incorporating information technology (IT) into a patient encounter takes skill and tact. During the encounter, the provider can make the patient more comfortable with the IT the provider is using by:
- A. Turning the screen around so the patient can see material being recorded
- B. Not placing the computer screen between the provider and the patient
- C. Both 1 and 2
- D. Neither 1 nor 2
Correct Answer: C
Rationale: Both actions reduce barriers and enhance patient comfort with IT use.
GLP-1 agonists:
- A. Directly bind to a receptor in the pancreatic beta cell
- B. Have been approved for monotherapy
- C. Speed gastric emptying to decrease appetite
- D. Can be given orally once daily
Correct Answer: A
Rationale: GLP-1 agonists bind beta-cell receptors to enhance insulin release; they're not monotherapy-approved or oral .
Which is known as the fifth vital sign?
- A. Temperature
- B. Respirations
- C. Pain
- D. Pulse
Correct Answer: C
Rationale: Pain is known as the fifth vital sign.
Choose an antihypertensive agent that is most likely to produce tachycardia, fluid retention and hirsutism?
- A. Captopril
- B. Guanethidine
- C. Minoxidil
- D. Prazosin
Correct Answer: C
Rationale: Minoxidil causes reflex tachycardia, fluid retention, and hirsutism.