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Cystic fibrosis most often affects multiple systems of the body. The primary factor responsible for possible multiple clinical manifestations is which of the following?

  • A. Hyperactivity of sweat glands
  • B. Hypoactivity of parasympathetic nervous system
  • C. Sweat chloride test >60 mEq/L
  • D. Increased viscosity resulting in mucous gland secretions
Correct Answer: D

Rationale: Cystic fibrosis (CF) is an inherited genetic disorder caused by mutations in the CFTR gene, leading to the production of thick, sticky mucus. This increased viscosity affects various organs and systems in the body, causing multiple clinical manifestations. The abnormal secretions block the airways in the lungs, leading to recurrent lung infections, breathing difficulties, and ultimately respiratory failure. In the digestive system, the thick mucus blocks the pancreatic ducts, impairing the release of digestive enzymes, which can result in malabsorption and malnutrition. Additionally, the thick secretions can affect the liver, leading to complications like liver disease. Therefore, the primary factor responsible for the multiple clinical manifestations in cystic fibrosis is the increased viscosity of the mucous gland secretions, which impacts various systems in the body.