ATI Capstone Pharmacology Assessment 1 Related

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Disulfiram is taken by a client daily for abstinence maintenance. What is an adverse effect of this therapy?

  • A. Hepatotoxicity
  • B. Wernicke's aphasia
  • C. Suicidal ideations
  • D. Diarrhea
Correct Answer: A

Rationale: The correct answer is A: Hepatotoxicity. Disulfiram is known to cause hepatotoxicity as a severe adverse effect. This occurs due to the inhibition of aldehyde dehydrogenase, leading to the accumulation of acetaldehyde when alcohol is consumed. Wernicke's aphasia (Choice B) is a language disorder unrelated to disulfiram therapy. Suicidal ideations (Choice C) may be associated with certain medications, but it is not a common adverse effect of disulfiram. Diarrhea (Choice D) is not a typical adverse effect of disulfiram.