Nokea
Drug efficacy' refers to..
- A. The range of diseases in which the drug is beneficial
- B. The maximal intensity of response that can be produced by the drug
- C. The therapeutic dose range of the drug
- D. The therapeutic index of the drug
Correct Answer: B
Rationale: Efficacy is defined as the maximum effect a drug can produce, per pharmacological principles.
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Ciprofloxacin increases the toxicity of theophylline by
- A. Inhibiting metabolism
- B. Decreasing excretion
- C. Decrease seizure threshold
- D. Promote absorption
Correct Answer: B
Rationale: Ciprofloxacin reduces theophylline clearance, decreasing excretion.
Beta blockers have favorable effects on survival and disease progression in heart failure. Treatment should be initiated when the:
- A. Symptoms are severe
- B. Patient has not responded to other therapies
- C. Patient has concurrent hypertension
- D. Left ventricular dysfunction is diagnosed
Correct Answer: D
Rationale: Beta blockers are initiated upon diagnosis of left ventricular dysfunction to improve outcomes.
Which of the following is corresponding to the following statement: this drug is used for diabetes mellitus and while using there is an increased risk of pancreatitis:
- A. Miglitol
- B. Pioglitazon
- C. Exenatide
- D. Glimepiride
Correct Answer: C
Rationale: Exenatide, a GLP-1 agonist, treats diabetes and has a known risk of pancreatitis as a rare but serious side effect.
Drug studies generally base the recommended adult dose of a drug needed to reach a critical concentration on what measure?
- A. A 60-year-old man
- B. An average-sized woman
- C. A 150-pound adult male
- D. An obese adult
Correct Answer: C
Rationale: Drug dosages are often standardized based on a 150-pound adult male as a common reference in pharmacological studies.
Substrate concentration & velocity curve indicates
- A. Michelis-Mentons equation
- B. Inverse relation
- C. Zero order kinetics
- D. All of the above
Correct Answer: C
Rationale: Substrate concentration vs. velocity in zero-order kinetics shows saturation, unlike first-order (Michaelis-Menten).