HESI A2 Biology Practice Test Related

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During which phase of mitosis does the nuclear envelope disintegrate?

  • A. Prophase
  • B. Prophase
  • C. Prometaphase
  • D. Metaphase
Correct Answer: C

Rationale: During the prometaphase stage of mitosis, the nuclear envelope disintegrates. This allows the condensed chromosomes to move towards the center of the cell, preparing for their alignment along the metaphase plate. The breakdown of the nuclear envelope is a crucial step in mitosis to ensure the proper segregation of genetic material into daughter cells. Choices A, B, and D are incorrect as the nuclear envelope disintegration specifically occurs during the prometaphase stage, not in prophase or metaphase.