Nokea
Following is the example of second generation antihistaminic:
- A. Diphenhydramine
- B. Promethazine
- C. Chlorpheniramine
- D. Cetirizine
Correct Answer: D
Rationale: Cetirizine is a second-generation antihistamine with less sedation due to reduced CNS penetration, unlike first-generation drugs like diphenhydramine, promethazine, and chlorpheniramine.
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A 60 year old male patient with a history of postural hypotension has just been diagnosed with benign prostatic hyperplasia. Which ONE of the following drugs is most suitable for the management of his condition?
- A. Prazosin
- B. Terazosin
- C. Doxazosin
- D. Tamsulosin
Correct Answer: D
Rationale: Tamsulosin, a selective alpha-1A blocker, minimizes postural hypotension compared to non-selective options.
Which of the following is used for treatment of hyperthyroidism:
- A. Liothironine
- B. Levothiroxine
- C. Propilthiouracil
- D. Liotrix
Correct Answer: C
Rationale: Propylthiouracil inhibits thyroid hormone synthesis, making it a standard treatment for hyperthyroidism.
Which of the following stimulated production of thyroid hormones:
- A. Thyrotropic hormone
- B. Corticosteroids
- C. Dopamine
- D. Somatostatine
Correct Answer: A
Rationale: Thyrotropic hormone (TSH) stimulates the thyroid to produce T3 and T4.
A nurse has been administering a drug to a patient intramuscularly (IM). The physician discontinued the IM dose and wrote an order for the drug to be given orally. The nurse notices that the oral dosage is considerably higher than the parenteral dose and understands that this is due to:
- A. Passive diffusion
- B. Active transport
- C. Glomerular filtration
- D. First-pass effect
Correct Answer: D
Rationale: The first-pass effect involves drugs that are absorbed from the small intestine directly into the portal venous system, which delivers the drug molecules to the liver. Once in the liver, enzymes break the drug into metabolites, which may become active or may be deactivated and readily excreted from the body. A large percentage of the oral dose is usually destroyed and never reaches tissues. Oral dosages account for the phenomenon to ensure an appropriate amount of the drug in the body to produce a therapeutic action. Passive diffusion is the major process through which drugs are absorbed into the body. Active transport is a process that uses energy to actively move a molecule across a cell membrane and is often involved in drug excretion in the kidney. Glomerular filtration is the passage of water and water-soluble components from the plasma into the renal tubule.
A nurse is assessing the patients home medication use. After listening to the patient list current medications, the nurse asks what priority question?
- A. Do you take any generic medications?
- B. Are any of these medications orphan drugs?
- C. Are these medications safe to take during pregnancy?
- D. Do you take any over-the-counter medications?
Correct Answer: D
Rationale: It is important for the nurse to specifically question use of over-the-counter medications because patients may not consider them important. The patient is unlikely to know the meaning of orphan drugs unless they too are health care providers. Safety during pregnancy, use of a generic medication, or classification of orphan drugs are things the patient would be unable to answer but could be found in reference books if the nurse wishes to research them.