Nokea
Following treatment with a highly efficient anti-tuberculosis drug a 48-yearold female developed optic nerve neuritis, memory impairment, cramps. Which of these anti-TB drugs had the patient taken?
Correct Answer: D
Rationale: Step 1: The symptoms of optic nerve neuritis, memory impairment, and cramps are indicative of ethambutol toxicity.
Step 2: Ethambutol is known to cause optic nerve toxicity leading to neuritis, as well as CNS toxicity causing memory impairment.
Step 3: Ethambutol can also lead to peripheral neuropathy manifesting as cramps.
Step 4: Isoniazid is associated with peripheral neuropathy and hepatotoxicity but not with optic nerve neuritis or memory impairment.
Step 5: PASA is not commonly used for tuberculosis treatment and does not cause the described symptoms.
Step 6: Rifampicin is known for hepatotoxicity and flu-like symptoms, but not specifically for optic nerve neuritis, memory impairment, or cramps.
Summary: Ethambutol is the correct answer due to its known side effects of optic nerve toxicity, CNS toxicity, and peripheral neuropathy, which align with the presented symptoms. Ison