Nokea
Granulomas containing lymphocytes and macrophages were detected during analysis of skin biopsy material. Among macrophages there are large cells with fat inclusions, which contain microorganisms in spheric packages (Virchow's cells). The following disease is based on the described type of hypersensitivity:
- A. Leprosy
- B. Syphilis
- C. Tuberculosis
- D. Rhinoscleroma
Correct Answer: C
Rationale: The correct answer is C: Tuberculosis. Granulomas with lymphocytes and macrophages containing Virchow's cells (large cells with fat inclusions containing microorganisms) are classic findings in tuberculosis. Leprosy (A) typically presents with granulomas but with different histopathological features. Syphilis (B) does not usually form granulomas in the skin. Rhinoscleroma (D) is a chronic bacterial infection characterized by nodular lesions but does not typically involve Virchow's cells as seen in tuberculosis.
You may also like to solve these questions
Microscopy of stained (Ziehl-Neelsen staining) smears taken from the sputum of a patient with chronic pulmonary disease revealed red bacilli. What property of tuberculous bacillus was shown up?
- A. Acid resistance
- B. Alkali resistance
- C. Alcohol resistance
- D. Capsule formation
Correct Answer: A
Rationale: The correct answer is A: Acid resistance. Tuberculous bacilli are acid-fast bacilli, meaning they resist decolorization by acid-alcohol after staining with Ziehl-Neelsen stain. This property is due to the high lipid content in the cell wall of Mycobacterium tuberculosis. Alkali resistance (B) and alcohol resistance (C) are not specific properties of tuberculous bacilli. Capsule formation (D) is a characteristic of some bacteria but is not a defining feature of tuberculous bacilli.
The optimal PH for most pathogenic bacteria and viruses is:
- A. 5.0-5.5
- B. 8.0-9.6
- C. 7.2-7.4
- D. 4.2-4.4
Correct Answer: C
Rationale: The correct answer is C (7.2-7.4) because most pathogenic bacteria and viruses thrive in a neutral pH environment close to 7.0. This pH range is optimal for their growth and survival. Choice A (5.0-5.5) is too acidic for most pathogens. Choice B (8.0-9.6) is too alkaline, which is not conducive for their survival. Choice D (4.2-4.4) is also too acidic and would likely inhibit the growth of pathogenic bacteria and viruses. Thus, a pH range of 7.2-7.4 provides the most suitable conditions for their proliferation.
Saprophytes are microorganisms which:
- A. Can induce typical infection
- B. Cannot induce infectious disease
- C. Can induce chronic infection
- D. Can induce mixed infection
Correct Answer: B
Rationale: The correct answer is B: Cannot induce infectious disease. Saprophytes are microorganisms that obtain nutrients from decaying organic matter and do not cause infectious diseases in humans. They play a vital role in the ecosystem by decomposing dead organisms. Choice A is incorrect because saprophytes do not cause typical infections. Choice C is incorrect because saprophytes do not cause chronic infections. Choice D is incorrect because saprophytes do not cause mixed infections involving multiple pathogens. Therefore, the correct answer is B as saprophytes do not induce infectious diseases.
A child with fever and a sore throat had a Gram-stained smear revealing Gram-positive cocci in chains. The bacteria were beta-hemolytic. What is the likely causative agent?
- A. Streptococcus pyogenes
- B. Streptococcus pneumoniae
- C. Staphylococcus aureus
- D. Enterococcus faecalis
Correct Answer: A
Rationale: The correct answer is A: Streptococcus pyogenes. The presence of Gram-positive cocci in chains suggests a streptococcal infection. Beta-hemolysis indicates the production of a hemolysin that lyses red blood cells, a characteristic of Streptococcus pyogenes. This bacterium is known to cause strep throat and can present with fever and sore throat.
Summary:
- B: Streptococcus pneumoniae is a common cause of pneumonia but typically appears as lancet-shaped cocci, not in chains.
- C: Staphylococcus aureus is a gram-positive cocci in clusters, not chains, and is not typically beta-hemolytic.
- D: Enterococcus faecalis is a gram-positive cocci that are part of the normal gut flora and are not typically beta-hemolytic or found in chains.
A patient with a sore throat and fever had a throat culture revealing Gram-positive cocci in pairs with a capsule. What is the most likely causative agent?
- A. Streptococcus pneumoniae
- B. Staphylococcus aureus
- C. Neisseria meningitidis
- D. Klebsiella pneumoniae
Correct Answer: A
Rationale: The correct answer is A: Streptococcus pneumoniae. This bacterium is a Gram-positive cocci that often appear in pairs and can have a capsule. It is a common cause of sore throat and fever, known as streptococcal pharyngitis. Staphylococcus aureus (B) is a Gram-positive cocci but does not typically form pairs. Neisseria meningitidis (C) is a Gram-negative diplococcus and is more associated with meningitis. Klebsiella pneumoniae (D) is a Gram-negative rod and not typically associated with sore throat and fever.