HESI A2 Biology 2024 Related

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In an example of a male with hemophilia and a female carrier, what ratio of the offspring are predicted neither to carry nor to manifest the disease?

  • A. 0 females : 1 male
  • B. 1 female : 1 male
  • C. 1 female : 0 males
  • D. 2 females : 1 male
Correct Answer: D

Rationale: In this scenario, the male offspring will inherit the Y chromosome from the father and the X chromosome from the carrier mother. As a result, they will not have the hemophilia gene. The female offspring will inherit one X chromosome from the mother, which does not carry the hemophilia gene, and one X chromosome from the father, which does not exist due to the Y chromosome. Therefore, all female offspring will not carry or manifest hemophilia, resulting in a ratio of 2 females to 1 male. Choice A is incorrect because it does not account for the female offspring. Choices B and C are incorrect as they do not reflect the correct ratio based on the inheritance pattern of hemophilia.