Licorice root is a common treatment for dyspepsia. Drug interactions with licorice include:
- A. Antihypertensives, diuretics, and digoxin
- B. Antidiarrheals, antihistamines, and omeprazole
- C. Penicillin antibiotic class and benzodiazepines
- D. None of the above
Correct Answer: A
Rationale: Licorice affects potassium levels and blood pressure, interacting with antihypertensives, diuretics, and digoxin.
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Which is the most important drug in the treatment of organophosphate poisoning?
- A. Atropine sulfate
- B. Pralidoxime
- C. Diazepam
- D. Adrenaline
Correct Answer: A
Rationale: Atropine sulfate is the most critical initial treatment for organophosphate poisoning, counteracting muscarinic effects like bronchorrhea and bradycardia, while pralidoxime regenerates cholinesterase later.
The following drugs are correctly paired with a clinical use EXCEPT:
- A. Tiludronate to treat Paget's disease of bone
- B. Raloxifene to prevent osteoporosis
- C. Picamycin to treat hypercalcemia
- D. Parathyroid hormone treats hypocalcemia
Correct Answer: D
Rationale: Parathyroid hormone treats osteoporosis, not hypocalcemia; calcitonin or bisphosphonates treat hypocalcemia.
When involved in phase III drug evaluation studies, what responsibilities would the nurse have?
- A. Working with animals who are given experimental drugs
- B. Choosing appropriate patients to be involved in the drug study
- C. Monitoring and observing patients closely for adverse effects
- D. Conducting research to determine effectiveness of the drug
Correct Answer: C
Rationale: Phase III studies involve use of a drug in a vast clinical population in which patients are asked to record any symptoms they experience while taking the drugs. Nurses may be responsible for helping collect and analyze the information to be shared with the Food and Drug Administration (FDA) but would not conduct research independently because nurses do not prescribe medications. Use of animals in drug testing is done in the preclinical trials. Select patients who are involved in phase II studies to participate in studies where the participants have the disease the drug is intended to treat. These patients are monitored closely for drug action and adverse effects. Phase I studies involve healthy human volunteers who are usually paid for their participation. Nurses may observe for adverse effects and toxicity.
Patients who are beginning therapy with vitamin B12 need to be monitored for:
- A. Hypertensive crisis that may occur in the first 36 hours
- B. Hypokalemia that occurs in the first 48 hours
- C. Leukopenia that occurs at 1 to 3 weeks of therapy
- D. Thrombocytopenia that may occur at any time in therapy
Correct Answer: B
Rationale: Hypokalemia can occur early in B12 therapy as red cell production surges, shifting potassium; other effects are rare.
The health care provider (HCP) prescribes exenatide (Byetta) for a client with type 1 diabetes mellitus who takes insulin. The nurse knows that which of the following is the appropriate intervention?
- A. The medication is administered within 60 minutes before the morning and evening meal.
- B. The medication is withheld and the HCP is called to question the prescription for the client.
- C. The client is monitored for gastrointestinal side effects after administration of the medication.
- D. The insulin is withdrawn from the Penlet into an insulin syringe to prepare for administration.
Correct Answer: B
Rationale: Exenatide (Byetta) is an incretin mimetic used for type 2 diabetes mellitus only. It is not recommended for clients taking insulin. Hence, the nurse should hold the medication and question the HCP regarding this prescription. Although options 1 and 3 are correct statements about the medication, in this situation the medication should not be administered. The medication is packaged in prefilled pens ready for injection without the need for drawing it up into another syringe.