Nokea
Long-acting beta-agonists (LTBAs) received a Black Box Warning from the U.S. Food and Drug Administration due to the:
- A. Risk of life-threatening dermatological reactions
- B. Increased incidence of cardiac events when LTBAs are used
- C. Increased risk of asthma-related deaths when LTBAs are used
- D. Risk for life-threatening alterations in electrolytes
Correct Answer: C
Rationale: The FDA Black Box Warning for LTBAs highlights increased asthma-related mortality risk, not dermatologic , cardiac , or electrolyte issues.
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While taking an angiotensin II receptor blocker (ARB), patients need to avoid certain over-the-counter drugs without first consulting the provider because:
- A. Cimetidine is metabolized by the CYP 3A4 isoenzymes
- B. Nonsteroidal anti-inflammatory drugs reduce prostaglandin levels
- C. Both 1 and 2
- D. Neither 1 nor 2
Correct Answer: B
Rationale: NSAIDs reduce prostaglandins, counteracting ARB's renal protective effects.
The nurse knows that which medication requires monitoring of thyroid function?
- A. Dofetilide
- B. Amiodarone
- C. Sotalol
- D. Flecainide
Correct Answer: B
Rationale: Amiodarone can cause hypo- or hyperthyroidism due to its iodine content, necessitating thyroid function monitoring.
Which of the following is a stimulative mechanism of insulin secretion:
- A. Hyperglicemia and decrease of intracellular ATP
- B. Increase of intracellular ATP and opening of ATP-depended K+ channels
- C. Increase of intracellular ATP and closure of ATP-depended K+ channels
- D. Closure of potential depended Ca+2 channels
Correct Answer: C
Rationale: Insulin secretion is stimulated by increased ATP closing K+ channels, depolarizing beta cells and opening Ca2+ channels.
Valerian tea causes relaxation and can be used to help a patient fall asleep. Overdosage of valerian (more than 2.5 gm/dose) may lead to:
- A. Cardiac disturbances
- B. Central nervous system depression
- C. Respiratory depression
- D. Skin rashes
Correct Answer: A
Rationale: Valerian overdose can cause cardiac disturbances due to its sedative effects.
A nurse is caring for an older adult client who has a new prescription for Digoxin and takes multiple other medications. The nurse should recognize that concurrent use of which of the following medications places the client at risk for Digoxin toxicity?
- A. Phenytoin
- B. Verapamil
- C. Warfarin
- D. Aluminum hydroxide
Correct Answer: B
Rationale: Verapamil increases digoxin levels by reducing clearance, risking toxicity.