Health Promotion and Maintenance NCLEX PN Questions Related

Review Health Promotion and Maintenance NCLEX PN Questions related questions and content

Narrow therapeutic index medications:

  • A. are drug formulations with limited pharmacokinetic variability.
  • B. have limited value and require no monitoring of blood levels.
  • C. have less than a twofold difference in minimum toxic levels and minimum effective concentration in the blood.
  • D. have limited potency and side effects.
Correct Answer: C

Rationale: The therapeutic index is the ratio between the median lethal dose and median effective dose of a drug. It provides a general indication of the margin of safety of a drug. Choice 1 is incorrect because pharmacokinetics is the process of adsorption, distribution, metabolism, and elimination. Choice 2 is incorrect because narrow therapeutic index drugs require close monitoring since there is often little difference between the desired drug effect and toxicity. Choice 4 is incorrect because narrow therapeutic index drugs have the potential for severe toxic effects with only slight increases in the dose or slight decreases in elimination.