Nokea
Patients receiving heparin therapy require monitoring of:
- A. Platelets every 2 to 3 days for thrombocytopenia that may occur on day 4 of therapy
- B. Electrolytes for elevated potassium levels in the first 24 hours of therapy
- C. INR throughout therapy to stay within the range of 2.0
- D. Blood pressure for hypertension that may occur in the first 2 days of treatment
Correct Answer: A
Rationale: Heparin can cause thrombocytopenia (HIT) around day 4, requiring platelet checks; INR is for warfarin, not heparin.
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Beta-1 receptors are found in the heart and kidney, whereas beta-2 receptors are found in the lungs, gastrointestinal tract, vascular smooth muscle, and skeletal muscle.
- A. TRUE
- B. FALSE
Correct Answer: A
Rationale: This is a correct description of beta receptor distribution.
An order is written for a patient to receive 1000 mL of normal saline IV over 8 hours. If the IV infusion set is a microdrip set that delivers 60 drops/mL, how many drops per minute should the patient be receiving?
- A. 60 drops/min
- B. 120 drops/min
- C. 240 drops/min
- D. 480 drops/min
Correct Answer: B
Rationale: If a patient were to receive 1000 mL in 8 hours, dividing 1000 by 8 would mean that the patient would receive 125 mL in 1 hour, or 60 minutes. Setting up the equation, 60 drops/mL X = 125 mL/60 min, and cross-multiplying, the answer is 120 drops/min.
The following adverse effects are associated with niacin EXCEPT:
- A. Flushing and itching
- B. Hypercuricemia
- C. Hyperglycemia
- D. Pellagra
Correct Answer: D
Rationale: Pellagra is caused by niacin deficiency, not an adverse effect of niacin therapy.
Carvedilol is heavily metabolized by CYP2D6 and 2C9, resulting in drug interactions with which of the following drug classes?
- A. Histamine 2 blockers
- B. Quinolones
- C. Serotonin re-uptake inhibitors
- D. All of the above
Correct Answer: C
Rationale: SSRIs inhibit CYP2D6, increasing carvedilol levels and effects.
A 6 year old child was admitted to the emergency unit with suspicion of an accidental overdose of chlordiazepoxide. Which of the following antagonists may be administered as part of the initial treatment?
- A. Flumazenil
- B. Naloxone
- C. Fomepizole
- D. Nalorphine
Correct Answer: A
Rationale: Flumazenil reverses benzodiazepine (e.g., chlordiazepoxide) overdose.