Nokea
Regarding cisapride:
- A. It is licensed for use in children
- B. Fatal arrhythmias have been reported
- C. Concurrent administration with erythromycin is not advised
- D. It commonly causes constipation
Correct Answer: B
Rationale: Fatal arrhythmias have been reported: Cisapride, a gastrointestinal prokinetic agent, has been linked to fatal arrhythmias, particularly when combined with certain drugs like erythromycin.
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A 15-year-old female reports fainting at school in class on two occasions. The adolescent's orthostatic blood pressures are normal. The primary care pediatric nurse practitioner suspects a cardiac cause for these episodes and will order which tests before referring her to a pediatric cardiologist?
- A. 12-lead electrocardiogram
- B. Echocardiogram
- C. Tilt table testing
- D. Treadmill exercise testing
Correct Answer: A
Rationale: A 12-lead ECG is useful for initial evaluation.
Recognised causes of delayed speech include:
- A. Hypothyroidism
- B. PKU
- C. Cystinuria
- D. Twins
Correct Answer: A
Rationale: Hypothyroidism is a known cause of delayed speech. PKU and deafness can also cause speech delays, but cystinuria is not associated with speech delay.
Recurrent Neisserial meningitis in children is suggestive of deficiency of ----- complement.
- A. C3
- B. C4
- C. C8
- D. All
Correct Answer: C
Rationale: Recurrent Neisserial meningitis is suggestive of a deficiency in the terminal complement components, particularly C8, which is crucial for bacterial lysis.
Which is a major clinical manifestation of rheumatic fever?
- A. Polyarthritis
- B. Osler nodes
- C. Janeway spots
- D. Splinter hemorrhages of distal third of nails
Correct Answer: A
Rationale: Polyarthritis, which is swollen, hot, red, and painful joints, is a major clinical manifestation of rheumatic fever. The affected joints will change every 1 to 2 days. Primarily the large joints are affected. Osler nodes, Janeway spots, and splinter hemorrhages are characteristic of infective endocarditis.
Duchenne muscular dystrophy:
- A. Has an association with malignant hyperpyrexia
- B. Is a reason for never running properly
- C. Is better diagnosed with muscle biopsy than gene probe
- D. Is associated with speech delay
Correct Answer: D
Rationale: Duchenne muscular dystrophy is associated with speech delay due to progressive muscle weakness, including facial muscles affecting speech.