Nokea
Sadie was prescribed betaxolol ophthalmic drops by her ophthalmologist to treat her glaucoma. Oral beta blockers should be avoided in patients who use ophthalmic beta blockers because:
- A. There may be an antagonistic reaction between the two
- B. The additive effects may include bradycardia
- C. They may potentiate each other and cause respiratory depression
- D. The additive effects may cause metabolic acidosis
Correct Answer: B
Rationale: Ophthalmic betaxolol can add to oral beta blockers, risking bradycardia; respiratory or acidosis are less likely.
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In the blood glucocorticoids cause:
- A. Increase amount of eosinophles
- B. Lymphocytosis
- C. Increase amount of neutrophils
- D. Increase amount of basophiles
Correct Answer: C
Rationale: Glucocorticoids increase neutrophils while decreasing eosinophils and lymphocytes in the blood.
Phase IV clinical trials in the United States are also known as:
- A. Human bioavailability trials
- B. Post marketing research
- C. Human safety and efficacy studies
- D. The last stage of animal trials before the human trials begin
Correct Answer: B
Rationale: Phase IV is post-marketing research , monitoring drugs after approval, unlike earlier phases or animal studies.
Select the first choice drug for acute gout:
- A. Colchicine
- B. Indomethacin
- C. Allopurinol
- D. Dexamethasone
Correct Answer: B
Rationale: Indomethacin, an NSAID, is the first-line treatment for acute gout due to its rapid anti-inflammatory action; colchicine is an alternative, while allopurinol is for prophylaxis.
The antidote for paracetamol poisoning is:
- A. Acetylsalicylic acid
- B. Acetylcysteine
- C. Prostacyclin
- D. Omeprazole
Correct Answer: B
Rationale: Acetylcysteine replenishes glutathione, detoxifying paracetamol's toxic metabolite.
Rho immune globulin (RhoGAM) is given to:
- A. Infants born to women who are Rh positive
- B. Sexual partners of Rh-positive women
- C. Rh-negative women after a birth, miscarriage, or abortion
- D. Rh-negative women at 36 weeks gestation
Correct Answer: C
Rationale: RhoGAM prevents Rh sensitization in Rh-negative women post-delivery; it's not for infants , partners , or late gestation alone.