Nokea
The catarrhal stage of the whooping cough is characterized by:
- A. Decrease in paroxysms of coughing
- B. Subsequent respiratory infection for many months after the onset of pertussis
- C. Uncontrollable coughing followed by a high pitched 'whoop' sound
- D. Mild respiratory symptoms (mild coughing, sneezing or a runny nose)
Correct Answer: D
Rationale: The correct answer is D because the catarrhal stage of whooping cough is characterized by mild respiratory symptoms such as mild coughing, sneezing, or a runny nose. During this stage, the cough may start to worsen but is not yet severe.
A: Incorrect - Decrease in paroxysms of coughing is not seen in the catarrhal stage; it occurs later in the paroxysmal stage.
B: Incorrect - Subsequent respiratory infection for many months after the onset of pertussis is not a characteristic of the catarrhal stage.
C: Incorrect - Uncontrollable coughing followed by a high pitched 'whoop' sound is typical of the paroxysmal stage, not the catarrhal stage.
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Ribosomes take part in:
- A. protein synthesis
- B. break down of different substances
- C. oxidative phosphorylation
- D. inactivation of antibiotics
Correct Answer: A
Rationale: Ribosomes are responsible for protein synthesis, where they translate the genetic information from mRNA into specific amino acid sequences to form proteins. This process occurs in both prokaryotic and eukaryotic cells. Ribosomes do not participate in the breakdown of substances, which is mainly carried out by lysosomes or proteasomes. Oxidative phosphorylation involves the generation of ATP in mitochondria, not ribosomes. Ribosomes do not inactivate antibiotics; this is typically done by enzymes or chemical modifications. Therefore, the correct answer is A as ribosomes play a crucial role in protein synthesis.
A patient suffering form tuberculosis was treated with rifampicin, which caused drug resistance of tuberculosis mycobacteria. In order to reduce mycobacteria resistance, rifampicin should be combined with the following drug:
- A. Isoniazid
- B. Acyclovir
- C. Intraconazole
- D. Metronidazole
Correct Answer: A
Rationale: The correct answer is A: Isoniazid. When rifampicin is used alone, there is a risk of developing resistance. Isoniazid is commonly used in combination with rifampicin to prevent resistance by targeting different mechanisms in the bacteria. Isoniazid works by inhibiting mycolic acid synthesis, while rifampicin targets RNA polymerase. This combination therapy is known as the first-line treatment for tuberculosis. Choices B, C, and D are incorrect because they do not have the same mechanism of action as isoniazid and would not be effective in preventing rifampicin resistance.
The so-called “red tide†is generally caused by which of the following organisms?
- A. Lichens
- B. Bacteria
- C. Pfiesteria
- D. Dinoflagellates
Correct Answer: D
Rationale: The correct answer is D: Dinoflagellates. Red tides are caused by the rapid growth of certain species of dinoflagellates, which are single-celled algae. These algae produce toxins that can harm marine life and humans. Lichens (A) are not associated with red tides. While some bacteria (B) can contribute to harmful algal blooms, they are not the primary cause of red tides. Pfiesteria (C) is a type of harmful algal species, but it is not the main organism responsible for red tides. Therefore, the correct answer is dinoflagellates (D) due to their ability to cause red tides through toxin production.
Acne is caused by:
- A. Staphylococcus aureus
- B. Staphylococcus epidermidis
- C. Streptococcus pyogenes
- D. Propionibacterium acnes
Correct Answer: D
Rationale: The correct answer is D: Propionibacterium acnes. This bacterium plays a key role in acne formation by colonizing hair follicles, leading to inflammation and acne lesions. It produces fatty acids that contribute to the development of acne. Staphylococcus aureus (A) and Staphylococcus epidermidis (B) are not directly linked to acne. Streptococcus pyogenes (C) is associated with skin infections but not acne. In summary, Propionibacterium acnes is the primary bacterium responsible for acne due to its ability to induce inflammation and follicular blockages.
A patient who has been taking tetracycline for a long time has developed candidosis of mucous membranes. What drug shoul administered for its treatment?
- A. Itraconazole
- B. Griseofulvin
- C. Nitrofungin
- D. Amphotericin
Correct Answer: A
Rationale: The correct answer is A: Itraconazole. Itraconazole is an antifungal medication commonly used to treat candidosis. It works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes. This action disrupts the integrity of the fungal cell membrane, leading to cell death. Griseofulvin (B) is primarily used to treat fungal infections of the skin and nails, not mucous membranes. Nitrofungin (C) is not commonly used for candidosis treatment. Amphotericin (D) is a potent antifungal medication but is typically reserved for severe or systemic fungal infections due to its potential side effects.