Nokea
The most frequent type of drug-food interaction is food:
- A. Causing increased therapeutic drug levels
- B. Affecting the metabolism of the drug
- C. Altering the volume of distribution of drugs
- D. Affecting the gastrointestinal absorption of drugs
Correct Answer: D
Rationale: Food most commonly affects drug absorption in the GI tract by altering pH, delaying gastric emptying, or binding to drugs, impacting bioavailability.
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Before prescribing phentermine to Sarah, a thorough drug history should be taken including assessing for the use of serotonergic agents such as selective serotonin reuptake inhibitors (SSRIs) and St John's wort due to:
- A. Additive respiratory depression risk
- B. Additive effects affecting liver function
- C. The risk of serotonin syndrome
- D. The risk of altered cognitive functioning
Correct Answer: C
Rationale: Phentermine with serotonergic agents increases serotonin syndrome risk.
In the liver insulin facilitates:
- A. Lypolisis
- B. Inhibit lipolysis
- C. Enhance lipoprotein lipase activity and support hydrolysis of triglycerides from lipoproteins
- D. Decrease production of glycerol phosphate and esterification of fatty acids
Correct Answer: B
Rationale: Insulin inhibits lipolysis in the liver, reducing fatty acid release.
Beta blocker are used in all, except
- A. Variant angina
- B. Mild hypertension
- C. Glaucoma
- D. Thyrotoxicosis
Correct Answer: A
Rationale: Beta-blockers worsen variant angina due to unopposed alpha constriction.
Which of the following is not used for hyperthyroidism:
- A. Triiodthironine
- B. Mercazolil
- C. Diiodthironine
- D. Potassium iodide
Correct Answer: A
Rationale: Triiodothyronine (T3) is a thyroid hormone, not a treatment for hyperthyroidism, unlike the others.
What patient populations would the nurse expect is most likely to be prescribed a drug for an off-label use?
- A. Adolescent and middle-aged adult patients
- B. Patients with diabetes or heart disease
Correct Answer: B
Rationale: Patients with chronic conditions like diabetes or heart disease are more likely to receive off-label prescriptions due to limited standard treatment options or the need for alternative therapies when conventional drugs are ineffective. Adolescents and middle-aged adults are less likely unless specific conditions warrant it, but the document cuts off, and based on clinical context, chronic disease patients are a common focus for off-label use.