Gastrointestinal NCLEX Questions Related

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The nurse is administering a proton pump inhibitor to a client diagnosed with peptic ulcer disease. Which statement supports the rationale for administering this medication?

  • A. It prevents the final transport of hydrogen ions into the gastric lumen.
  • B. It blocks receptors controlling hydrochloric acid secretion by the parietal cells.
  • C. It protects the ulcer from the destructive action of the digestive enzyme pepsin.
  • D. It neutralizes the hydrochloric acid secreted by the stomach.
Correct Answer: A

Rationale: Proton pump inhibitors (PPIs) inhibit the H+/K+ ATPase pump, preventing hydrogen ion transport into the gastric lumen, thus reducing acid production to promote ulcer healing. Blocking receptors is for H2 antagonists, pepsin protection is for mucosal agents, and neutralization is for antacids.