HESI RN Exit Exam 2023 Capstone Related

Review HESI RN Exit Exam 2023 Capstone related questions and content

The nurse is planning to administer two medications at 0900. Which property of the drugs indicates a need to monitor the client for toxicity?

  • A. Short half-life
  • B. High therapeutic index
  • C. Highly protein-bound
  • D. Low bioavailability
Correct Answer: C

Rationale: The correct answer is C, 'Highly protein-bound.' Drugs that are highly protein-bound can displace from protein-binding sites, leading to increased free drug levels in the blood, which can result in toxicity. Monitoring the client for toxicity is crucial when administering highly protein-bound drugs. Choices A, B, and D are incorrect. A short half-life does not necessarily indicate a need for monitoring toxicity; a high therapeutic index indicates a wide safety margin between the effective dose and the toxic dose, reducing the risk of toxicity; low bioavailability refers to the fraction of the drug that reaches the systemic circulation unchanged and does not directly relate to the risk of toxicity.