Nokea
The nurse is reinforcing teaching to a person being tested for HIV in a clinic. Which test should the nurse explain is done first in HIV testing?
- A. ELISA test
- B. Western blot test
- C. Viral load studies
- D. Rheumatoid factor test
Correct Answer: A
Rationale: The correct answer is A: ELISA test. The ELISA test is typically the initial screening test for HIV due to its high sensitivity in detecting HIV antibodies. It is cost-effective and quick. Western blot test is a confirmatory test used if ELISA is positive. Viral load studies monitor the progression of the disease but are not typically done first. Rheumatoid factor test is unrelated to HIV testing. Therefore, the ELISA test is the most appropriate initial step in HIV testing.
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To raise antibodies that interfere with the interaction of HIV with CD4+ T cells, vaccines should target which of the following HIV antigens
- A. gp41
- B. Reverse transcriptase
- C. gp120
- D. Matrix proteins
Correct Answer: C
Rationale: The correct answer is C: gp120. This is because gp120 is a key HIV antigen that plays a crucial role in binding to CD4 receptors on T cells, facilitating viral entry. By targeting gp120, vaccines can induce antibodies that block this interaction, preventing HIV from infecting CD4+ T cells. Conversely, choices A, B, and D (gp41, Reverse transcriptase, Matrix proteins) are not as effective targets for interfering with the CD4+ T cell interaction, as they do not directly impact the initial binding and entry process of HIV into the cells.
Which immunoglobulin is the principal one found in secretions such as milk?
- A. IgG
- B. IgM
- C. IgA
- D. IgD
Correct Answer: C
Rationale: The correct answer is C: IgA. IgA is the principal immunoglobulin found in secretions like milk due to its role in mucosal immunity. IgG is mainly found in the blood and provides systemic immunity. IgM is the first antibody produced during an immune response. IgD is primarily found on the surface of B cells and is involved in B cell activation. IgA is the most abundant immunoglobulin in mucosal secretions, making it the principal one found in milk.
How do regulatory T cells (Tregs) maintain immune homeostasis?
- A. By killing infected cells
- B. By producing pro-inflammatory cytokines
- C. By suppressing immune responses using IL-10
- D. By activating macrophages
Correct Answer: C
Rationale: Regulatory T cells (Tregs) maintain immune homeostasis by suppressing immune responses using IL-10. Tregs release IL-10, which inhibits the activity of effector T cells and other immune cells, preventing excessive immune responses and maintaining balance. This mechanism helps prevent autoimmune diseases and chronic inflammation. Choices A, B, and D are incorrect because Tregs do not kill infected cells, produce pro-inflammatory cytokines, or activate macrophages. Instead, Tregs focus on regulating and dampening immune responses to maintain overall immune balance.
Identify the fluid that is least possible to transmit AIDS.
- A. Blood
- B. Breast milk
- C. Semen
- D. Saliva
Correct Answer: D
Rationale: The correct answer is D: Saliva. Saliva has very low levels of HIV, making it least likely to transmit AIDS. HIV transmission requires direct contact with infected bodily fluids containing high viral loads, such as blood, breast milk, and semen. Saliva does not typically contain enough HIV to transmit the virus, as it has enzymes that can inhibit HIV. Therefore, the risk of HIV transmission through saliva is extremely low compared to the other fluids listed.
Which statement indicates that the patient needs further instruction about application of ice to a sprain?
- A. "I know this ice will reduce the swelling."
- B. "I will keep the ice on this knee for the rest of the day."
- C. "I will use the ice as you have directed for 24 hours."
- D. "I can elevate my leg and use ice to reduce swelling."
Correct Answer: B
Rationale: The correct answer is B because keeping ice on the knee for the rest of the day can lead to skin damage or frostbite. Choice A is correct as it acknowledges the purpose of ice in reducing swelling. Choice C shows understanding of using ice as directed. Choice D indicates proper understanding of combining elevation with ice for swelling reduction.