NCLEX Pharmacology Questions Related

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The nurse practicing in a long term care facility recognizes that elderly clients are at greater risk for drug toxicity than younger adults because of which of the following physiological changes of advancing age?

  • A. Drugs are absorbed more readily from the GI tract
  • B. Elders have less body water and more fat
  • C. The elderly have more rapid hepatic metabolism
  • D. Older people are often malnourished and anemic
Correct Answer: B

Rationale: Elders have less body water and more fat. Because elderly persons have decreased lean body tissue/water in which to distribute medications, more drug remains in the circulatory system with potential for drug toxicity. Increased body fat results in greater amounts of fat-soluble drugs being absorbed, leaving less in circulation, thus increasing the duration of action of the drug.