Nokea
The nursing instructor is discussing drug therapy in the older adult. What would the instructor tell the students could affect therapeutic dosing in an older adult?
- A. In older adults, drugs have decreased GI absorption.
- B. In older adults
- C. In older adults, drugs are distributed to a smaller portion of the tissue.
- D. In older adults, drugs have an increased action.
Correct Answer: A
Rationale: Decreased GI absorption in older adults can reduce drug bioavailability, necessitating dosage adjustments.
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The nurse explains that what drug resource book is compiled from package inserts?
- A. Nurses Drug Guide
- B. Physicians Desk Reference (PDR)
- C. Drug Facts and Comparisons
- D. AMA Drug Evaluations
Correct Answer: B
Rationale: The PDR is a compilation of information found on package inserts. The Nurses Drug Guide uses more easily understood language and incorporates nursing considerations and patient teaching points. Drug Facts and Comparisons includes cost comparison, often not found in other drug resource guides. The AMA Drug Evaluations is far less biased than the PDR and includes drugs still in the research stage of development.
All nonsteroidal anti-inflammatory drugs (NSAIDS) have an FDA Black Box Warning regarding:
- A. Potential for causing life-threatening GI bleeds
- B. Increased risk of developing systemic arthritis with prolonged use
- C. Risk of life-threatening rashes, including Stevens-Johnson
- D. Potential for transient changes in serum glucose
Correct Answer: A
Rationale: NSAIDs carry a Black Box Warning for GI bleeding risk; rashes or glucose aren't highlighted.
An disorder develops lactic acidosis, and nearly dies, as a result of an uncommon but serious adverse response to therapy with an 'endocrine' drug. Which of the following was the most likely cause of this severe problem?
- A. Insulin glargine, prescribed for Type 1 diabetes mellitus
- B. Levothyroxine, prescribed to maintain euthyroid status following thyroidectomy
- C. Metformin, prescribed for Type 2 diabetes mellitus
- D. Propylthiouracil, prescribed for hyperthyroidism
Correct Answer: C
Rationale: Metformin is the most likely cause of lactic acidosis, a rare but life-threatening complication.
Aminoglycosides are most effective against which kind of microorganism?
- A. Aerobic gram-negative bacteria
- B. Anaerobic gram-negative bacteria
- C. Aerobic gram-positive bacteria
- D. Anaerobic gram-positive bacteria
Correct Answer: A
Rationale: Aminoglycosides target aerobic gram-negative bacteria by inhibiting protein synthesis, requiring oxygen-dependent uptake.
A client asks the NP about the differences in drug effects between men and women. What is known about the differences between the pharmacokinetics of men and women?
- A. Body temperature varies between men and women.
- B. Muscle mass is greater in women.
- C. Percentage of fat differs between genders.
- D. Proven subjective factors exist between the genders.
Correct Answer: C
Rationale: Gender differences in pharmacokinetics are largely due to fat percentage , affecting drug distribution; muscle mass is greater in men (B is false), and temperature/subjective factors are less impactful.