Practice NCLEX RN Test Related

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The physician has prescribed imipramine (ToFranil) for a client with depression. The nurse should continue to monitor the client's affect because the maximal effects of tricyclic antidepressant medication do not occur for:

  • A. 48-72 hours
  • B. 5-7 days
  • C. 2-4 weeks
  • D. 3-6 months
Correct Answer: C

Rationale: Tricyclic antidepressants like imipramine take 2-4 weeks to reach maximal therapeutic effect, requiring ongoing monitoring of the client's mood.