Pediatric Emergency Nursing PICO Questions Related

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The physician prescribes didanosone (ddl [Videx]), 200mg PO every 12 hours, for a client with acquired immunodeficiency syndrome (AIDS) who is intolerant to zidovudine (azidothymidine ,AZT [Retrovir]). Which condition in the client's history warrants cautious of this drug?

  • A. Peripheral neuropathy
  • B. Hypertension
  • C. Diabetes mellitus
  • D. Asthma
Correct Answer: A

Rationale: Didanosine (ddl or Videx) is an antiretroviral medication used in the treatment of HIV/AIDS. However, one of the notable side effects of didanosine is peripheral neuropathy, which can manifest as tingling, numbness, or pain in the hands and feet. Since the client already has a history of peripheral neuropathy, prescribing didanosine may exacerbate this condition, making it important for the healthcare provider to exercise caution. Monitoring for any signs or symptoms of worsening peripheral neuropathy is essential in this case.