Nokea
The primary action of loop diuretics is to:
- A. Inhibit sodium and chloride reabsorption in the loop of Henle.
- B. Block aldosterone receptors in the distal tubule.
- C. Increase osmolarity of the renal tubular fluid.
- D. Inhibit sodium reabsorption in the proximal tubule.
Correct Answer: A
Rationale: Loop diuretics like furosemide inhibit Na+/Cl- reabsorption in the loop of Henle, increasing urine output.
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The commonest side effect of pioglitazone in the treatment of Type II diabetes mellitus is:
- A. Fluid retention
- B. Hypoglycemia
- C. Lactic acidosis
- D. Pancreatitis
Correct Answer: A
Rationale: Pioglitazone, a PPAR-gamma agonist, commonly causes fluid retention.
Avoid concurrent administration of exenatide with which of the following drugs?
- A. Digoxin
- B. Warfarin
- C. Lovastatin
- D. All of the above
Correct Answer: D
Rationale: Exenatide delays gastric emptying, potentially affecting absorption of digoxin , warfarin , and lovastatin .
Slow channel syndrome is due to
- A. Accumulation of Na+ ions in channels
- B. Accumulation of K+ ions in channels
- C. Accumulation of Mg++ ions in channels
- D. Accumulation of Ca++ ions in channels
Correct Answer: D
Rationale: Slow channel syndrome relates to calcium channel dysfunction.
A patient wants to know about the possible interactions of the various drugs that he has been prescribed for an illness. The nurse explains that the drugs interact with each other and produce an effect that is greater than the sum of their separate actions. Which of the following reactions is the nurse informing about?
- A. Additive drug reaction
- B. Synergistic drug reaction
- C. Antagonistic drug reaction
- D. Toxic drug reaction
Correct Answer: B
Rationale: A synergistic drug reaction occurs when drugs interact with each other and produce a sum greater than the sum of their separate actions. An additive drug reaction occurs when the combined effect of two drugs is equal to the sum of each drug given alone. An antagonistic drug reaction occurs when one drug interferes with the action of another, causing neutralization or a decrease in the effect of one drug. Toxic drug reactions are caused when blood concentration levels exceed the therapeutic levels of a drug.
The following are recognized effects of propranolol except
- A. Increases microcoronary blood flow
- B. Decrease in heart rate
- C. Decrease in cardiac output
- D. Reduction in ventricular systolic pressure
Correct Answer: A
Rationale: Propranolol reduces coronary flow; other effects are correct.